A new process in bio-chemistry involves the manipulation of
molecules to defeat diseases, viruses, chemical warfare,
and to reduce the cost of bio-chemical engineering. This
new process is refined in that the researcher utilizes new
computer technology to model the behavior of certain
molecules before inserting a "slot" for discarding unwanted
foreign objects. These unwanted foreign objects are
discarded by fixing the slot to fit the objects. This slot
can be customized, through manipulation and modelling, to
fit many different objects. Therefore, objects such as
viruses, poisonings, or bacteria, could be jetted out of
ones body. This aspect could one day benefit millions of
people around the world.
Teams from universities successfully inserted instructions
for building an anti-fluorescein antibody in the DNA of
bacteria. This antibody binds with fluorescein molecules.
Into this chunk of material, they inserted instructions for
buildin g a metal-ion binding sight. They discovered where
to put this slot by simulating the antibody on a large
computer. The resulting product revealed an
anti-fluorescein antibody which binds to metal ions. After
physically inserting the genetic code in to E. coli.
bacteria, the researchers had a large batch of a new
compound which they named QM212. When copper was added to
this new batch, it binded with the metal-ion binding sight,
decreasing the fluorescent emissions.
The human immune system already uses similar antibodies for
similar tasks. Natural antibodies conform to the shape of
foreign bodies and bind to the outer surface. They then
release enzymes to break down the substance. In the
experiment, copper acted as the foreign body while QM212
was the antibody.
One application of this process could be used by the
military. The military, utilizing bio-chemical tools, could
engineer an antibody which binds with nerve gas and splits
each molecule. This could be accomplished by first of all
searching the Brookhaven database for a proper antibody.
Then, using large mainframe computers, one can manipulate
models of the antibody and create a binding sight for the
nerve gas molecules. Then, the soldier would inject himself
with the antibodies when he is nerve gased.
Another application of this process could be used by bio─
chemists in fighting the AIDS epidemic. If an antibody was
engineered to conform to the AIDS virus, it could break it
in half and dispose of it.
Finally, using E. coli., synthetic antibodies replacing
current vaccines could be mass produced. Instead of growing
cultures of a disease then killing them for use in
vaccines, one could produce one antibody which conforms to
the disease the n reproduce this with E. Coli.
The impact of these applications could benefit people
around the world. Soldiers would not die (and continue
killing like blind mice) because of the nerve gas serum.
The AIDS epidemic would halt as announcements of a new
product which would desist the AIDS virus fill the radio
waves. AIDS is increasing exponentially and this would halt
its fatal expansion. Also, biologists would no longer waste
money in replicating vaccines. A mini-computer would be
used to replicate synthetic antibodies instead.
Creating molecules with the uncanningly precise seek-and─
destroy capabilities of natural antibodies is an exciting
step in replicating nature's fascinating immune system.
Uehling, Mark D. "Birth of a Molecule." February 1992, p. 74